Fallout is officially packing its bags for New Vegas in Season 2, and yes, that means Mr. House is entering the chat. Justin Theroux is your live-action House, and the casting quietly links the show to a big piece of Star Trek history. Let’s break it down.
Mr. House goes live-action, with a Star Trek twist
In the 2010 game Fallout: New Vegas (developed by Obsidian and published by Bethesda on PC, PS3, and Xbox 360), Mr. House was voiced by René Auberjonois — the same René Auberjonois who played Odo on Star Trek: Deep Space Nine for seven seasons. His performance as House had that gravelly, patrician snap to it, turning the character into a post-apocalyptic Howard Hughes: charming when it suited him, menacing when it didn’t. Fans noticed.
I can’t help but feel chills every time this guy speaks. I’d go so far as to say he’s the best voiced character in Fallout so far, even Liam Neeson as James couldn’t match the kind of ability this guy put into his character.
Auberjonois died in December 2019 at 79, but his take on Mr. House left a mark that still gets both Trekkies and Fallout players buzzing.
Justin Theroux is the new House — and he did the homework
You’ve probably seen Theroux anchoring The Leftovers, popping up in The Last Jedi for a quick, cheeky cameo, or stealing scenes in Poker Face. Now he’s stepping into Mr. House’s very expensive shoes for Fallout Season 2. According to GQ, once he signed on, he dove into YouTube gameplay and lore to soak up how House talks and operates — the right move when you’re taking over a character fans treat like canon royalty.
Why this casting actually makes a lot of sense
Auberjonois gave House that cool, calculating rasp; Theroux excels at complex, layered guys who can turn on a dime. The show is run by Geneva Robertson-Dworet and Graham Wagner, who already proved in Season 1 that they can respect the games while giving actors room to do something fresh. Put that together, and the handoff from the game’s voice legend to a live-action heavy-hitter feels smart, not stunt-y.
Quick cheat sheet
- Where we’re headed: New Vegas, in Fallout Season 2
- The character: Mr. House — one of the franchise’s most iconic power players
- Then: René Auberjonois voiced House in Fallout: New Vegas (2010), built by Obsidian and published by Bethesda on PC, PS3, and Xbox 360; Auberjonois is also Odo from Star Trek: Deep Space Nine; he passed away in December 2019 at age 79
- Now: Justin Theroux plays House in live action for the TV series
- Theroux prep: per GQ, he binged gameplay videos to absorb House’s cadence and choices
- Strengths comparison: Auberjonois brought that raspy, menacing charm; Theroux is known for nuanced, layered performances
- Showrunners: Geneva Robertson-Dworet and Graham Wagner
- Release: Fallout Season 2 premieres December 17, 2025, exclusively on Prime Video
The bottom line
Passing Mr. House from Auberjonois’s legendary voice to Theroux’s live-action presence nicely ties the show’s next chapter back to the game while opening the door to a new take. If Season 1 is anything to go by, this should work.
Fallout Season 2 hits Prime Video on December 17, 2025. I’m curious where Theroux lands between charm and threat — and how weird the New Vegas of it all gets. Your move, House.