Grey’s Anatomy Star Reveals When Every Doctor’s Fate Will Be Decided

Grey's left us on a literal bang at Grey Sloan, so naturally the first question heading into Season 22 is: who made it out? Camilla Luddington, a.k.a. Jo, just dropped some careful hints about the premiere, and yes, it sounds like the show is about to stress us all out in the way only Grey's can.

What Camilla Luddington is saying about the premiere

At the Step Up 2025 Inspiration Awards, Luddington told People that the Season 22 opener is stacked. She says every scene lands hard, the story load is heavy, and it honestly feels like a two-hour episode even though it isn’t. Her words for the vibe: intense, and 'explosive' — and yes, she knows exactly what she did there.

She also framed it as vintage Grey's: the parts you love and the choices that make you want to throw something at your TV. Expect a mix of wins and gut-punches. Luddington, 41, made it clear fans are going to be both relieved and wrecked — sometimes in the same stretch of minutes.

'You will have to wait until the end... sometimes even a little bit into the next episode.'

That’s her on when we actually learn the fates of the doctors after the blast. So, yes, Episode 1 pushes you right to the edge, and some answers may spill into Episode 2.

Also worth noting: she called it rough to film. Not fun. A ride. Which usually means the actors were put through it so we can be put through it.

• Fate reveal: By the end of the premiere, with a few payoffs possibly rolling into Episode 2
• Tone: Intense, packed, and 'explosive'; classic Grey's highs and lows that may have you yelling at your TV
• When to watch: Season 22 premieres at 10 p.m. ET on ABC; streams on Hulu the next day
• Who’s in: Ellen Pompeo, Chandra Wilson, James Pickens Jr, Kevin McKidd, Camilla Luddington, and more

If you’ve been bracing since that Grey Sloan explosion, you won't be waiting long — but you might be white-knuckling it right up to the credits.